Since the grand opening of Hotel New Otani Osaka in 1986, the hotel has been the chosen venue of numerous international conferences, commemorative ceremonies, seminars and parties.

| Banquet Room | Buffet | School | Theater | Area | ||
|---|---|---|---|---|---|---|
| 18F | Sunset | 125m2 | ||||
| Rainbow | 88m2 | |||||
| 2F | THE-HŌ | Open Room | 3,000 | 1,600 | 3,000 | 2,380m2 |
| THE-HŌ | 2,000 | 800 | 1,700 | 1,650m2 | ||
| THE-HŌ I | 300 | 330 | 600 | 590m2 | ||
| THE-HŌ II | 200 | 280 | 560 | 450m2 | ||
| THE-HŌ III | 400 | 390 | 650 | 610m2 | ||
| THE-HŌ S | 500 | 420 | 780 | 675m2 | ||
| MANHATTAN CRANE | 80 | 82 | 154 | 179m2 | ||
| NEW YORK SWAN | 80 | 82 | 154 | 174m2 | ||
| ALTAIR | 40 | 32 | 60 | 78m2 | ||
| VEGA | - | - | - | 78m2 | ||
| DENEB I | 30 | 24 | 50 | 59m2 | ||
| DENEB II | 30 | 24 | 50 | 59m2 | ||
| DENEB III | 30 | 24 | 50 | 59m2 | ||
| B1F | Iris | 130 | 128 | 250 | 216m2 | |
| Wisteria | 130 | 128 | 250 | 216m2 | ||
| Cattleya | 100 | 96 | 220 | 193m2 | ||
| Primrose | 100 | 96 | 220 | 193m2 | ||
| Cosmos | 40 | 28 | 60 | 66m2 | ||
| Lilac | 40 | 28 | 60 | 66m2 | ||
| Bellflower | 40 | 28 | 60 | 66m2 | ||